AI-Assisted Diagnostics

Paige’s AI-assisted diagnostic and biomarker AI applications meet the highest standards and are designed to support some of the most challenging cancer cases.

AI-Assisted Diagnostic Applications

Paige Prostate Suite

The Paige Prostate Suite is a group of comprehensive AI-powered applications that aid in the detection and grading of prostate cancer on H&E-stained whole-slide images of prostate needle biopsies.

  • Paige Prostate Detectii - Assists in the detection of foci suspicious for cancer
  • Paige Prostate Grade & Quantify* - Categorizes areas suspicious for cancer by Gleason pattern, providing a primary and secondary Gleason grade prediction, as well as a percentage and linear measurement of tumor burden
  • Paige Prostate Perineural Invasion (PNI)* - Aids in the detection of suspicious foci around nerve fibers, identifying the presence of PNI

Paige Breast Suite

The Paige Breast Suite is a set of AI-powered applications that support in the identification and classification of breast cancer on H&E-stained whole-slide images from breast biopsy and excision specimens.

  • Paige Breast Detect & Neoplasm* - Highlights foci suspicious for cancer and pre-cancerous neoplasms
  • Paige Breast Mitosis* - Identifies individual mitotic figures, locates the mitotic hotspot, and automatically calculates mitotic counts mitotic density
  • Paige Breast Lymph Node* - Detects foci that are suspicious for breast cancer metastasis from lymph node specimens
  • HER2Completeii – an AI assay that can measure HER2 expression from H&E samples, including the identification of HER-2 low patients

Paige GI Suite

The Paige GI Suite is a new and powerful portfolio of AI-powered applications designed to support pathologists in the detection and classification of benign and malignant condition across the entire gastrointestinal tract.  Built off Paige’s latest foundation model technology this represents the most powerful range of diagnostic AI applications for GI pathology.

  • Paige GI Detect & Subtype† - Detect, classify and localize cancer, pre-cancer and benign lesions in biopsies and resection specimens from anywhere across the GI systems including esophagus, stomach, small intestine, gall bladder, pancreas, large bowel and rectum
  • Paige Colon Detect* - Identifies foci suspicious for colon carcinoma and high-grade dysplasia (HGD)
  • Paige Colon MSI+ - Detects the presence or absence of high microsatellite instability (MSI-H) or mismatch repair-deficient (dMMR) phenotypes from colon biopsies and resections containing cancer

Paige Pan-Cancer Detect

A novel, first of its kind application that can detect regions of interest suspicious for cancer across multiple organs and different tissues, including GI, GU, lung, cervix, endometrium, breast, skin, brain and rare cancer variants.

  • In digital workflows, can be used to prioritize cases for accelerated workflow

How pathologists are using Paige’s AI-assisted diagnostic applications

Every day, pathologists leverage Paige's AI applications to enhance their diagnostic confidence, improve workflow efficiencies, and ultimately deliver better patient care. From image analysis and decision support to workflow automation, Paige is being used to support hospitals and labs worldwide.

By harnessing the capabilities of Paige’s lab-tested AI applications, pathologists around the world are enhancing their diagnostic confidence, improving workflow efficiencies, and ultimately delivering better patient care. From image analysis and decision support to workflow automation, Paige is being used daily.  

Reduce false negative rates and provide quality assurance

Prioritize cases or individual slides by identifying those suspicious for cancer 

Quickly identify an area on the slide most suspicious for cancer, including hard-to-find or small cancers

Automate laborious diagnostic tasks including measurement, quantification, and classification 

Seamless Integration Across Digital Pathology Platforms

Leveraging Paige’s AI open strategy, we enable seamless deployment across multiple scanners, image formats and digital pathology platforms. So whether you are using an established platform or exploring new digital IMS options, Paige will work with you to ensure a seamless AI experience and fit effortlessly into your lab workflows.

"The authorization of this AI-based software can help increase the number of identified prostate biopsy samples with cancerous tissue, which can ultimately save lives."

— Office of In Vitro Diagnostics and Radiological Health, FDA Center for Devices and Radiological Health

    1Eloy C, Marques A, Pinto J, et al. Artificial intelligence–assisted cancer diagnosis improves the efficiency of pathologists in prostatic biopsies. Virchows Arch. 2023. doi: 10.1007/s00428-023-03518-5 2da Silva LM, Pereira EM, Salles PGO, et al. Independent real-world application of a clinical-grade automated prostate cancer detection system. J Pathol. 2021;254(2):147–158. doi: 10.1002/path.5662 3Raciti P, Sue J, Retamero JA, et al. Clinical Validation of Artificial Intelligence–Augmented Pathology Diagnosis Demonstrates Significant Gains in Diagnostic Accuracy in Prostate Cancer Detection [published online ahead of print, 2022 Dec 20]. Arch Pathol Lab Med. 2022. doi: 10.5858/arpa.2022-0066-OA 4Retamero, Juan Antonio MD, MSc; Gulturk, Emre MSc; Bozkurt, Alican MSc; Liu, Sandy MD; Gorgan, Maria MD; Moral, Luis MD; Horton, Margaret PhD; Parke, Andrea PhD; Malfroid, Kasper MSc; Sue, Jill MS; Rothrock, Brandon PhD; Oakley, Gerard MD; DeMuth, George MS; Millar, Ewan BSc, FRCPath,§; Fuchs, Thomas J. DSc,∥,; Klimstra, David S. MD. Artificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases. The American Journal of Surgical Pathology 48(7):p 846-854, July 2024. | DOI: 10.1097/PAS.0000000000002248 5Flach RN, van Dooijeweert C, Nguyen TQ, Lynch M, Jonges TN, Meijer RP, Suelmann BBM, Willemse PM, Stathonikos N, van Diest PJ. Prospective Clinical Implementation of Paige Prostate Detect Artificial Intelligence Assistance in the Detection of Prostate Cancer in Prostate Biopsies: CONFIDENT P Trial Implementation of Artificial Intelligence Assistance in Prostate Cancer Detection. JCO Clin Cancer Inform. 2025 Mar;9:e2400193. doi: 10.1200/CCI-24-00193. Epub 2025 Mar 4. PMID: 40036728. 6Vorontsov, E., Bozkurt, A., Casson, A. et al. A foundation model for clinical-grade computational pathology and rare cancers detection. Nat Med 30, 2924–2935 (2024). https://doi.org/10.1038/s41591-024-03141-0 **In the United States, Paige Prostate Detect (DEN200080) is approved for clinical use with Philips Ultrafast Scanner. iRefer to the product-specific labeling for the regulatory status of each AI-Assisted Diagnostic Application. When Research Use Only products are used with IVD products, the integrated workflow will be for Research Use Only (RUO) and cannot be used for diagnostic procedures. iiCE-IVD marked. In the US, Paige Prostate Detect is approved to assist pathologist in the detection of foci that are suspicious for cancer as detailed in the intended use https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/denovo.cfm?id=DEN200080 *CE-IVD marked. For Research Use Only (RUO) in the US. Not for use in diagnostic procedures in the US. +For Research Use Only (RUO). Not for use in diagnostic procedures. † The Paige GI Suite is currently under development and not available for use.